Most of the function buttons are placed in the perfect spot for me and I was able to customise it precisely to my needs. The focus assist has been moved to a dedicated button on the back, where in the past you used the back command control wheel to zoom in on your picture or for manual focus. Each directional button is also customisable. There is a love/hate relationship between me and the Fn-button on the front of the camera. I have set it up to quickly change my custom settings, however while this makes changing it easy, it is also very easy to bump, and I find it accidentally changes back to Custom 1 very easy.
The sub-dials right under the shutter dial allow you to quickly set the metering type, while under the ISO you have an array of options that used to be in the DRIVE menu: BKT, CH, CL, S, multiple exposures, advanced filters and pano.
The ISO dial is great, even though initially I wasn't sure I liked the lock that you have to press to move it. But as I got used to it, I found it was not too much of an annoyance anymore. They did add an ISO "L", which makes it 100. I have not tried this out yet, guessing it may come in handy when you need to go beyond the 1/4000 limit on the shutter.
The EV-dial is the one thing I absolutely don't agree with or understand why they felt the need to make it so much bigger than any of the other models and requires two fingers to adjust. I personally think they should have used the one on the X100/s, to me that size and rigidness is perfect.
Like the X-E2, there is a top Fn-button for Wifi, which can be defined, but has been moved to below the shutter button.
The shutter button can not be controlled by cable release anymore, but there is a very cool remote control app available on Android or iOS, more on that later. Right next to it is the record-button for movies, but I've found this placement a little annoying, as it used to be the place of the well-used Fn-button for ISO, and there's been a few times I've actually put it in movie mode accidentally. The people that are into making movies, might find this placement useful.